CONSIDERATIONS TO KNOW ABOUT LSD VIAL

In the LSD-bound crystal composition, the side chain from the lid residue L209EL2 kinds considerable hydrophobic contacts with each LSD and surrounding residues in TMs III, IV, and V (Figure 4C). If the lid moved apart to show the binding pocket in simulation, several of such contacts broke. We Hence hypothesized that L209EL2 acts as a latch, lower